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Our results show that in vivo TRF2 abrogation in a highly proliferative tissue such as skin leads to the most severe deleterious effect as compared to TRF1, TPP1, and RAP1 loss (Martinez et al., 2009, 2010; Tejera et al., 2010).
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In its most severe form, uremic pruritus is associated with significant deleterious impairments of patient quality of life, including depression and disruption of sleep [ 1, 2].
In conclusion, our comprehensive study has demonstrated that chronic SCI has deleterious effects on the entire skeleton, with the most severe bone loss and structural deterioration in the lower extremities followed by sublesional vertebrae.
Traffic courts are most severe.
20 00 most severe crisis".
-Who suffered the most severe punishment?
Only the most severe get any help".
Also small doses of very toxic substances can lead to severe deleterious effects.
Or prioritize the potentially most severe ones?
They had stopped the most severe issue within seven hours.
The most severe complication was abscess (1.1%).
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