Sentence examples for most severe changes from inspiring English sources
Some colic horses showed extremely high plasma lactate concentrations before surgery, the most severely ill horses usually having the most severe changes.
Steam + 5% acetic acid pretreatment was found to cause the most severe changes to the EFBF surface.
Carbonate dominated (i.e. >2% TIC) and mixed (i.e. clay containing) sediments showed the most severe changes in water chemistry with large increases in all major and trace elements coupled to minimal reductions in pH due to high buffering capacity.
The most severe changes were in the cerebellum, the researchers report in the 15 November Annals of Neurology; this region is typically characterized by loss of Purkinje cells, which integrate information.
"Although ocean acidification is a global phenomenon, emerging research indicates that the U.S.-Canadian West Coast will face some of the earliest, most severe changes in ocean carbon chemistry," the report says.
The severity of ultrastructural changes to the RPE-Bruch membrane-choroid was rated using a scale of 0 (no change) to 3 (most severe changes)according to our previously published protocol based on Cousins et al, and semi-quantified using regression analysis [31].
However, our findings suggest that the majority and most severe morphological changes after treatment by SAG occur in the face, and we attribute these changes mainly to disruptions in SHH signaling.
In conclusion, Group B, presented the most severe inflammatory changes, involving all layers, while in Group C congestion and slight inflammatory reactions of the mucosa were observed.
The most severe morphologic changes, including electron-dense mitochondrial inclusions, were found in the fetuses with delayed recovery of the fetal heart rate after the final occlusion.
Similarly, the most severe histopathological changes were observed in the same two organs, although the gills and intestines were also affected.
In the mdx mouse, tongue, heart, diaphragm, and soleus muscles exhibit the most severe dystrophic changes, such as regeneration and degeneration with fibrosis [34], [35].
