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The most severe alterations were clearly found in adult testes [ 9].
Most severe alterations of the cardiovascular system were frequently seen in patients with septic shock.
This suggests that patients with the most severe alterations in hepatosplanchnic blood flow are also prone to decreased mucosal perfusion.
The most severe alterations were seen in layers III-VI, while layer II was affected to a lesser extent and only in some patients.
There is general agreement that measures aimed at limiting lung exposure to high pressures and volumes should be implemented, especially in patients with the most severe alterations in respiratory mechanics.
The consequence is an increased risk of barotrauma and volutrauma in the patients with the most severe alterations of respiratory mechanics, such as those observed in severe asthma, ARDS and lung fibrosis.
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Hyperkinetic patients exhibited the most severe alteration in afterload indices, and a worse outcome.
Patients with hypokinesia had an alteration in left ventricle contractility indices, whereas those with hyperkinesia exhibited the most severe alteration in afterload indices.
Hyperkinetic patients exhibited the most severe alteration in afterload indices and a higher in-ICU and in-hospital mortality as compared to others.
The most severe alteration in enzyme activity was observed in liver and may be due to its prime role in detoxification of the compound.
By analyzing and comparing the phenotypes of an allelic series of Nde1 Lis1 single and double mutations, our study showed that the most severe alteration of cell fate correlates tightly with the cell morphology and cytoarchitecture defects of radial glial neuroepithelial progenitors (Table 1).
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