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One limitation could be that most severe affected patients have to be excluded in this study.
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FGFR2 mutations are the most common and most severe affecting the coronal, metopic, sagittal, and lambdoid sutures.
Global cerebral amyloid angiopathy was assessed using a semiquantitative severity measure of 0 = none; 1 = mild; 2 = moderate; 3 = severe from the most severely affected region.
In the current experiments the mdx mouse pathology is most severe at the 4 week time point, while the Sgcg−/− mice are most severely affected at 12 weeks.
The evaluations were performed on the most severely affected lesions and graded as none, mild, moderate or severe (+++; figure 1).
In this study over half of those with exacerbation had moderate to severe cognitive impairment, most severely affecting executive function and associated with duration of hospitalisation and reduced quality of life.
The most severe cuts affect Medicare Advantage -- a popular private insurance option for seniors -- to the tune of $205 billion.
Advice to parents on the issue will be strengthened, although it will make clear that colourings are not the only - nor main - cause of hyperactivity in children, a chronic condition which may in its most severe form affect up to one in 20 people.
One of the most severe problems affecting China's sustainable urban development is the resource dependent city, in which resource mining and process industries dominate the local economy.
The most severe parasitosis affecting Alpine chamois is sarcoptic mange or scabies.
Third-degree burns are the most severe and dangerous, affecting all layers of the skin.
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CEO of Professional Science Editing for Scientists @ prosciediting.com