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The differences in the respective siderocalins suggest that each was developed in response to the most serious pathogens encountered by that animal.
As one of the most serious pathogens in the freshwater aquatic environment, spring viraemia of carp virus (SVCV) induces a high mortality rate in several cyprinid fishes.
Staphylococcus aureus is one of the most serious pathogens of humans and important animal pathogen.
Influenza has a history as one of the world's most serious pathogens, with yearly regional infections and episodic global pandemics.
Because Erwinia chrysanthemi is one of the most serious pathogens infecting Phalaenopsis, old leaves were infected with E. chrysanthemi to induce the expression of pathogen-related genes.
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P. infestans is the most serious pathogen of potatoes on a worldwide basis and control of this windborne pathogen is achieved only by a significant expenditure of pesticides [2].
The most serious pathogen affecting avocado production is Phytophthora cinnamomi which causes Phytophthora root rot (PRR).
The root-rot fungus Heterobasidion spp. species complex is the most serious pathogen on Norway spruce in Scandinavia [ 5] causing root and stem rot and rendering the timber defective for sawing and pulping.
Particularly, over the past decade, E. coli O157 H7 has been reported increasingly from all parts of the world and in the worst case, it is "one of the most serious" foodborne pathogens leading to severe illnesses and high mortality rates in humans (Blanco et al. 2003; Jo et al. 2004).
The most serious human pathogen among the tickborne viruses in the African region is Crimean-Congo hemorrhagic fever virus (CCHFV), a member of the Nairovirus genus that can cause fatal hemorrhagic disease (8, 9 ).
See related commentary by Kalil and Florescu, http://ccforum.com/content/15/2/138 Human cytomegalovirus (CMV) is widely recognized as the most serious viral pathogen in immunosuppressed patients, such as solid organ transplant recipients or those with malignant haematologic disorders or human immunodeficiency virus (HIV) infection [ 1- 6].
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