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The phrase "most serious impact" is grammatically correct and can be used in written English.
It is typically used to describe the significant or severe consequences of a certain event or action. Example: The earthquake had a most serious impact on the town, leaving many buildings destroyed and causing widespread damage.
Exact(13)
The projected increases in crop prices would have the most serious impact in poor countries.
However, the most serious impact of the tourism explosion has been to put pressure on the precarious water situation.
He said the most serious impact of the storm had been on agriculture - the loss of crops and livestock.
For Dr. Salins, the author of "Scarcity by Design: The Legacy of New York City's Housing Policies Harvard University Pressss, 1992), "The most serious impact of continued rent regulation is the misallocation of the housing stock".
The A.P.'s account was the fourth prominent Twitter account of a media organization to be hacked in recent months — accounts for CBS, NPR and the BBC have all been hijacked by hackers recently — but the A.P. incident had the most serious impact.
Mr Obstfeld added that the collapse in world commodity prices was having its most serious impact on exporters such as Brazil and Russia, and that emerging and developing economies looked set to experience a fifth straight year of falling GDP growth.
Similar(47)
"We can still avoid the most serious impacts.
So, at this crucial juncture in the calendar, with the window of opportunity for preventing the most serious impacts of climate change still open – but closing quickly – focusing our attention on finding potent images that will develop and enhance people's commitment to tackling the issue is a critical challenge.
Some of the most serious impacts from trade deals result not so much from the immediate lifting of trade restrictions but the creation of new advantages for foreign investors that lead to longer term changes in what and how people eat.
Indeed, one of the most serious impacts of abiotic stresses is 'yield penalty' i.e. reduction in grain yield (Hirayama and Shinozaki, 2010; Urano et al. 2010).
The Semi also boasts industry-leading safety fealties, according to Tesla, including a total inability to jackknife, enhanced Autopiilot features and glass that's designed to resist even the most serious impacts.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com