Sentence examples for most serious changes from inspiring English sources

A former managing director at the Strategic Rail Authority, the government body that oversaw the birth of Network Rail, said the proposals represented the most serious changes to the industry in a decade.

All that remained of a broad package of measures representing the most serious changes to the nation's gun laws in 20 years were two amendments: one that would address mental health care, and another that would penalize states that divulge information about gun owners except under very specific circumstances like a criminal investigation.

The most serious changes caused by asymmetrical load of the thoracic limbs in horses occur near the proximal metaphysis, where the spongious substance is most abundant.

Understanding the conditions that can lead to the most serious changes in the ENM dispersion (aggregation, dissolution, or photolysis) can help prevent these confounding factors.

The report, which effectively cleared the scientists of the most serious charges – including deliberately fudging climate change results, is unlikely to be the final word on the matter, as the University of East Anglia and the beleaguered director of its Climatic Research Unit, Phil Jones, would have hoped.

The OVX + PLF + V group showed the most serious degenerative changes, with the lowest disc height, highest endplate thickness, and largest ratio of calcified area to the total endplate area (vs. Sham + V: P < 0.001, P < 0.001, P < 0.001).

While many political observers consider an emergency shutdown of Amtrak unlikely, even the most optimistic say that serious changes are likely to be in store for Amtrak, which has controlled the nation's passenger rail system since 1971.

This surprisingly low estimate is based on a single study by government agencies that ignored the most serious threats from climate change.

"For Copenhagen, the most serious effect of climate change will be increased precipitation, so we've developed a plan that addresses how to catch all the rainwater in the city".

From what is known so far, among the most serious is that he changed his position on a tax loophole to benefit a company that was behind a $1 million pledge to the Charles B. Rangel Center for Public Service at City College.

So, at this crucial juncture in the calendar, with the window of opportunity for preventing the most serious impacts of climate change still open – but closing quickly – focusing our attention on finding potent images that will develop and enhance people's commitment to tackling the issue is a critical challenge.