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This action was the most serious challenge of his presidency.
The country's most serious challenge, she says, is to avoid "another lost decade" of low growth.
Yet the most serious challenge for Ennahda has been controlling the extremists among its followers.
Mr. Zhu called it "the most serious challenge for the whole world".
The uprising against his government poses the most serious challenge to his family's rule.
It proved to generate the most serious challenge to his 27-year rule.
The uprising is the most serious challenge to his family's 40 years of autocratic rule.
Then there is Arnold Schwarzenegger, the Republican who could pose the most serious challenge.
The report represents the most serious challenge yet to the rules underlying the fund.
Corbyn's most serious challenge, aside from a frenetically hostile media, will come from his own MPs.
His election presents the most serious challenge to the international order that has prevailed since 1945.
More suggestions(15)
most grievous challenge
most serious competition
most difficult challenge
most troubling challenge
most serious problem
most dangerous challenge
most worrisome challenge
most substantial challenge
most serious business
most serious habitat
most serious crime
most serious health
most serious flu
most serious breach
most serious symptom
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com