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In diffuse-type AIP, the Asian criteria were most sensitive with a sensitivity of 98.9%, followed by ICDC (93.7%) and the HISORt criteria (89.5%).
Among the different model routine parameters, the catchment parameter PCALT is the most sensitive, with moderate or high sensitivities for all objective functions.
The D375G,Y370F,Y374A,F376L mutant was the most sensitive, with a ki value of 2.2×106 moL−1 L min−1, three orders of magnitude higher than eeAChE (1.1×103 moL−1 L min−1).
In a combination exhibiting independent drug action, each patient benefits solely from the drug to which his or her tumor is most sensitive, with no added benefit from other drugs.
Age and seasonal aspects had strongest effects with juveniles and animals taken from a spring population being most sensitive with an EC50 (96 h) of 14.2 μg L−1 imidacloprid.
A431 cells were the most sensitive with derivatives 6e 6h bearing electron withdrawing substituents exhibiting high potency with IC50 values ranging between 2.18 and 0.54 μM and drastic inhibition of the prosurvival PI3K-Akt/PKB pathway.
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On the whole, the least susceptible pathogen was P. aeruginosa with sensitivities ranging from 20% to 80%, while Moraxella sp. represented the most sensitive pathogen with sensitivities ranging from 71.4% to 100%.
Furthermore the weights are still amongst the most sensitive parameters with a relative sensitivity of about 0.5-10.5-1%
This is more sensitive than conventional detection of Neu5Gc by DMB-derivatization and HPLC analysis with fluorescent detection [38] (previously the most sensitive method, with a detection limit of ∼10 20 pmoles, depending on the background).
With respect to EC50, sensitivity to each drug was cell-line specific, with neuroblastoma cells (NGP and SH-SY5Y) the most sensitive compared with the melanoma or glioblastoma cells.
On the contrary, S. aureus appeared to be the most sensitive one, with a sensible growth diminution since after the first hour with the minimum content of both ozonated oil and peroxide content.
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