These results support the conclusion that massively parallel sequencing is the most sensitive technology currently available in clinical mutation diagnostics and suggest that pyrosequencing might be an alternative to dideoxy sequencing.
Ultra-deep sequencing is undoubtedly the most sensitive technology currently available for mutation scanning.
The ability to detect small differences in telomere length may be influenced by the measurement technique used, therefore, it is important to select the most sensitive technology for the type of sample available.
Also, targeted mass spectrometry represented the most sensitive technology that allowed us to design assays for a number of target proteins without the need for specific reagents (e.g., antibodies).
One of the major bottlenecks is the scarce amount of sample that can typically be obtained, and therefore it is of crucial importance to deploy the most sensitive proteomics technologies and to keep investing in the development of such methodologies.
But, she added, even the most sensitive DNA technology can fail to detect a microbe if it is present in tiny amounts.
Marconi plans to emulate the business model of companies such as Cisco and outsource 70% of its manufacturing, keeping only the most sensitive high-technology stuff in-house.Marconi still has some of the rag-bag of smaller industrial interests from its past, such as medical electronics systems, petrol pumps and retail automation.
In this benchmarking study, we have analyzed 24 tumors from 22 patients (Table 1) for a systematic comparison of mutation detection performance of conventional dideoxy- and pyrosequencing against one of the most sensitive sequencing technology, massively parallel sequencing [20].
These have included ideas for "fuel assurances", so that countries do not feel the need to invest in the most sensitive fuel-making technologies, and also nuclear co-operation agreements.One such agreement between the United States and the United Arab Emirates (UAE) is due to enter into force in October.
We performed, in a clinical setting, a systematic validation of dideoxy 'Sanger' sequencing and pyrosequencing against massively parallel sequencing as one of the most sensitive mutation detection technologies available.
