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The most sensitive targets of cadmium toxicity are the kidney, bone and lung cancer.
Contrary to the hypothesis, orlistat at 1 nM inhibited CES2 activity by 75% but no inhibition on CES1, placing CES2 one of the most sensitive targets of orlistat.
Neural and blood cells are the most sensitive targets.
Many of these studies have focused on heart deformities as cardiac tissue is considered one of the most sensitive targets of dioxin toxicity in developing fish [4].
The most sensitive targets of enteric alpha defensins are Gram-positive and Gram-negative bacteria [ 12].
These results show that the adrenal gland is probably among the most sensitive targets of PBDE toxicity.
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DCs are arguably the most sensitive target cell for THI identified to date, and this sensitivity to oxidative insult may reflect a unique manner in which they generate and use Ca2+ signals in response to a changing redox environment.
The liver was also the most sensitive target organ for repetitive applications of PFOA in mice, rats, and primates.
When using the exposure/recovery protocol even for the most sensitive target organism, O. nubilalis, the lethal effect observed in the continuous exposure treatment also largely disappeared.
The most sensitive target organs for repetitive oral application of PFOS over a period of 4 weeks to 2 years in rats and cynomolgus monkeys were the liver and thyroid.
The results show clear differences in the response to mercury between the two groups of primary producers, with the most sensitive target systems being photosynthesis in phytoplankton, and the intermediary metabolism in macrophytes.
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Justyna Jupowicz-Kozak
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