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DWI is the most sensitive sequence in stroke diagnosis and provides information about prognosis.
Key points Ischaemia leads to DWI changes within minutes of symptom onset Pearls DWI helps in: Diagnosis (most sensitive sequence) Prognosis and treatment planning (DWI aids in "dating" the stroke and in achieving better patient selection) Pitfalls False negatives for posterior circulation strokes possible Open image in new window Fig. 2 Spinal cord ischaemia.
Using HHpred, which is one of the most sensitive sequence comparison programs and does not rely explicitly on spatial information [ 15] and the sequence model of G2 domain family derived from pfam07474, we observed several matches to cnidarian fluorescent proteins, with the borderline HHpred P-values from 0.0017 to 0.05.
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In this benchmarking study, we have analyzed 24 tumors from 22 patients (Table 1) for a systematic comparison of mutation detection performance of conventional dideoxy- and pyrosequencing against one of the most sensitive sequencing technology, massively parallel sequencing [20].
Hence, structural fold-based comparison indentified novel PTL which even the most sensitive sequence-based method could not detect.
They began by the most sensitive sequence-based search (PSI-BLAST) and followed through with careful multiple alignment and then structural modeling.
We also consider the evolutionary relationship between these families, whose sequences are so diverged that even most sensitive sequence-based method did not find any relation, yet their overall three-dimensional fold and active site pocket have been conserved to perform same function.
The enhanced accuracy is probably the result of the automated preselection of one of the five most sensitive sequences in the estimated liver iron concentration range.
For further analyses, only FLAIR and DWI were considered e.g. only the most sensitive sequences, FLAIR and DWI (Kallenberg et al., 2006), were considered.
Based on correlation with tracked biopsies, T2-weighted MRI and apparent diffusion coefficient maps derived from diffusion-weighted MRI are the most sensitive sequences, whereas the addition of delayed contrast enhancement MRI and three-dimensional magnetic resonance spectroscopy demonstrated higher specificity consistent with results obtained using radical prostatectomy specimens.
The FLAIR sequence was chosen for quantification because it is standard practice at our institution, and of the sequences available to us, it is the sequence most sensitive to tumour-induced changes.
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