Sentence examples for most sensitive rodent from inspiring English sources

In this regard, we have clearly shown that the S-D rat is not the most sensitive rodent for such testing.

The starting dose for the 1-h 3-weekly schedule was 0.23 mg m−2, that is, one-tenth of the maximum tolerated dose found for the most sensitive rodent species (mouse) in animal toxicology studies.

The authors call on scientists screening suspected endocrine disruptors to choose the most sensitive rodents, to minimize the animals' exposure to dietary estrogens, and to control their caloric intake.

This difference is especially pronounced in the subcutaneous fat deposits, which is expected, as subcutaneous fat pads have been shown to be the deposit most sensitive to GH regulation in rodents [23].

Neurobehavioral toxicity seems to be the most sensitive target of PBDEs in rodents that has been reported to date, although pronounced effects on thyroid homeostasis have been also reported (Hallgren and Darnerud 2002; Hallgren et al. 2001; Zhou et al. 2001 , 2002.

The most sensitive sites for these opioid effects in rodents are in the ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg).

Rodent SCCVII cells and repair deficient, radiation sensitive cells (rodent XR-1, V-3, and human AT5BI) were most sensitive to SR 4233 under hypoxia with a lethal dose needed to kill 50% of cells (LD50) of less than 5 microM.

Overall, the human blood- (Jurkat) and neuron-derived (SH-SY5Y) cells and rodent cells (N2a, H-4-II-E and NIH 3T3) were most sensitive to compound-induced cytotoxicity; kidney-derived cells (HEK293, human mesangial, and rat primary proximal tubule) were inter-mediate in sensitivity; and human fibroblastic, endothelial, and skin cells (HUV-EC-C, BJ, and MRC-5) were least sensitive.

In rodents, AGD has been shown to be one of the most sensitive end points for phthalates such as DBP (Mylchreest et al. 2000) and other antiandrogens such as flutamide (Barlow and Foster 2003; McIntyre et al. 2001) and finasteride (Bowman et al. 2003).

However, intact rodents are of limited value for this purpose because serum IGF-I, the most sensitive pharmacodynamic marker for the action of GH in humans, shows no response to treatment with recombinant human GH and there is little evidence for the effects of GHAs, except when administered at very high doses or when overexpressed.

It's the most sensitive.