Sentence examples for most sensitive pathway from inspiring English sources

In some cases such as pathway-based benchmark concentrations, we do not yet understand the relationship between the chemically most sensitive pathway and a specific toxicological outcome.

When applied to toxicogenomic data from flusilazole-exposed zebrafish embryos, benchmark concentration modeling identified retinol metabolism as the most sensitive pathway, with a pathway-based benchmark concentration no effect level much lower than the pathway-based NOEL and closer to observed values in adult fish and values predicted by ToxCast™ analyses (Table 3).

Benchmark dose (BMD) analysis on gene expression data revealed that Nrf2-mediated antioxidant response and protein ubiquitination were the most sensitive biological pathways that were activated in response to low concentrations of HOCl (< 0.35 mM).

The simplest readouts assess the most sensitive enriched units the enriched pathway with the lowest BMD.

Blood and HetA seem to be the most sensitive elements to piRNA pathway perturbation (Lim and Kai 2007; Sienski et al. 2012; Vagin et al. 2006).

We next systematically investigated the sensitivity of all the rate constants and found those whose perturbation the pathway is most sensitive or most robust against.

The foregoing in silico experiments revealed that the dynamic behaviour of the gp130/JAK/STAT pathway is most sensitive to two parameters: the rate of nuclear STAT3 de-phosphorylation and the rate of STAT3 nuclear export.

The MDA-MB-231 cell line was used to show Nrf2 activation for two reasons: first, MDA-MB-231 cells can be easily transfected; and second, the Nrf2 pathway is most sensitive in this cell line in response to Nrf2-inducers.

The bicarbonate sensitive pathway is the most important mechanism for active lithium influx into the cell [ 90].

Previous studies also showed that HEY genes are the most sensitive Notch target genes for Notch pathway inhibition in breast cancer (Leong et al, 2007).

The possibility exists that increased activated mTOR may help drive ligand-independent ERα signaling and short circuit the ligand-dependent pathway that is most sensitive to inhibition by endocrine therapies.