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Results also allow to identify the most sensitive nodes and the failure mechanisms associated to transient effects on this type of converter.
Identification of the most sensitive nodes in the death receptor pathways could allow to develop targeted therapies and new drugs that would allow to interfere with these diseases.
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Thus staging PLND remains the most sensitive method for assessing lymph node metastases and continues to be the first step in the management protocol.
Unlike the traditional, target-based screen that relies on a predefined, sometimes poorly validated target, a chemical genetics-based phenotypic screen efficiently interrogates entire metabolic or molecular signaling pathways in an unbiased manner for the most drug-sensitive node.
EUS is the best method for the T stage; it is also the most sensitive method for the assessment of local nodes but has limited specificity (Tables 2 and 3).
For the detection of regional lymph node metastases, EUS is most sensitive, whereas CT and FDG-PET are more specific tests.
KS1/4 was shown to be the most sensitive marker for detecting metastatic NSCLC in mediastinal lymph nodes using real-time RT-PCR [ 6].
The reason BW is the most sensitive to topology update interval is that, within a topology update interval, nodes with large bandwidth were allocated upstream in this method.
7 The most sensitive method for localization of a recurrent tumour mass or of lymph node metastases in the neck is, however, conventional high-resolution ultrasound which gives a sensitivity of around 96% and a specificity of 83%.
In a recent study, mammaglobins, and the third marker PIP, were found to be the most sensitive and specific markers for the detection of micrometastatic breast cancer in axillary lymph nodes (Mitas et al, 2003).
It has been shown that circulating B cells are most sensitive to rapid depletion as compared to the slow and incomplete depletion of B cells in spleen, lymph nodes, or bone marrow (BM).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com