The most sensitive mechanisms were related to the generation and degradation of the cyclin B-CDK1 complex otherwise known as the Maturation Promoting Factor (MPF) (Table 2).
The most sensitive global mechanism was the translational efficiency while local mechanisms such as activation of IE (hypothetical protein which activates the E3-ligase CDC20), expression of cyclin B and CDH1 degradation were also predicted to be fragile (Table 3, cluster I).
Activation of inactive MPF complex, whose expression is negatively regulated by p53, was the most sensitive G2 mechanism (Table 2, cluster I), followed by preMPF generation, activation and transport of CDC25 into the nucleus (Table 2, cluster II).
The S1 and S T of the most sensitive AT1RGRN mechanisms on AP-1, as identified in Figure 5A, at these time points is presented in Figures 5B, C, and 5D.
Interestingly, the time when AP-1 is most sensitive to these mechanisms is almost exactly the time in which AP-1 is predicted to be composed of equal parts ppc-Fos:ppc-Jun and ppc-Jun:ppc-Jun TF dimers.
The different damage processes affect the transport properties in different manner according to the distribution and density of induced cracks; water permeability seems to be the mechanism most sensitive to the type and size of coarse aggregate.
A long-wavelength-isolation condition (LW) was used for isolating cone mechanisms most sensitive to long wavelengths, dim and intense short-wavelength-isolation conditions (Dim-SW and SW) aimed at isolating cone mechanisms most sensitive to short wavelengths and a relatively spectrally flat background condition was used as a control.
After 20 minutes of Ang II treatment, ppc-Fos:ppc-Jun is predicted to be the dominant AP-1 dimer and, consequently, AP-1 is most sensitive to Fos reaction mechanisms.
Results also allow to identify the most sensitive nodes and the failure mechanisms associated to transient effects on this type of converter.
Non-dioxin-like (NDL) PCBs increase intracellular Ca2+ in neurons via several mechanisms, the most sensitive of which is potentiation of ryanodine receptor (RyR) activity (Pessah et al. 2010).
