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The EHS questionnaire devised by Eltiti et al. (2007b) was to be used for selecting the 132 most sensitive individuals.
The most sensitive individuals are diagnosed using low doses and only the more tolerant need to go on to be challenged orally, thus avoiding hospital bed use.
Reference Exposure Levels (RELs), as estimated by the OEHHA, 203) are designed to protect the most sensitive individuals in the population and include margins of safety.
These data can inform the air-quality standard-setting process to protect even the most sensitive individuals from adverse health effects with an adequate margin of safety.
Around one hundred individuals for each family were selected to evaluate both traits (the 50 most resistant and the 50 most sensitive individuals).
"We can't sample the bone marrow in exposed humans, but these results suggest that changes in blood may not reflect bone marrow toxicity among the most sensitive individuals," French says.
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Sensitivity studies show that the cation exchange selectivity coefficients were the most sensitive individual parameters determining the 90Sr distribution.
Thus, of these markers, CCR6 was the most sensitive individual marker of IL-17 production by CD4+ T cells, followed by CD161 and CD146.
These studies have failed to confirm the ability of even the most sensitive individual to detect exceedingly low concentrations of formaldehyde.
"What we sell is going to be out there for the general population to use, so we're compelled to protect the most sensitive individual," says George Daston, a senior toxicologist in the Central Product Safety group of Procter and Gamble.
Results: For about half the tested compounds, cytotoxic response in the 1% most "sensitive" individual occurred at concentrations within a factor of 10½ (i.e., approximately 3) of that in the median individual; however, for some compounds, this factor was > 10.
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