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Interspecies extrapolation factors (IEFs) have been derived for the most sensitive endpoints in laboratory animals.
The most sensitive endpoints in this study were 28 d growth and 56 d egg mass production, both with a NOEC of <1.0 μg L−1 and a LOEC of 1.0 μg L−1, showing that the ELS growth endpoint is predictive of the 56 d reproduction endpoint.
These two data sets are referred to as "most similar endpoints" and "most sensitive endpoints" in the following.
The second data set ("most sensitive endpoints") was derived from the list of endpoints identified during the European review process for new and existing a.s.s
Figure 5 illustrates the frequency distribution of the 230 non-censored MDR values obtained from the data set "most sensitive endpoints", excluding NOEC-based calculations.
This confirms that the approach of the "most sensitive endpoints" is the more conservative in comparison to the approach using "most similar endpoints".
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The most sensitive endpoint was the colloid, which showed alterations at ≥250 μg/L.
A meta-analysis of several rat toxicity studies for dimethoate was conducted to determine the most sensitive endpoint for use in risk assessment.
M. aeruginosa photosynthetic activity was found to be the most sensitive endpoint to enrofloxacin (EC50 72 h =0.02 mg/L), followed by growth inhibition based on cell number.
The freshwater pulmonate snail, Lymnaea stagnalis, is the most sensitive freshwater organism tested to date for several metals (Co, Cu, Pb, Ni) based on 28 d early life-stage (ELS) tests in which growth was the most sensitive endpoint.
In both chronic tests, the number of offspring was the most sensitive endpoint and significant effects were recorded at concentrations ≥50 mg/L (42-d experiment) and ≥12.5 mg/L (56-d experiment).
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