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For the advancement of in vitro testicular toxicity testing, one of the most sensitive end points in regulatory reproductive toxicity testing, such an investment is highly desirable.
did not cure the underestimation of product toxicity for the most sensitive end point (Fig. 2c).
Symbols for the most sensitive end point for each product are enlarged.
with regard to the most sensitive end point in 9 out of the 21 products.
There were three products (6, 16, and 20) with an underestimation of product toxicity for the most sensitive end point (algae).
In three other products (10, 22, and 23), toxicity for the most sensitive end point was overestimated by the CA prediction, in one case more than tenfold (fish for product 22).
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An overall no observed adverse effect level (NOAEL) of 5 mg BPA/kg bw/day was derived, based on liver weight decreases, the most sensitive end-point.
The Organisation for Economic Co-operation and DevelOECD/SIDSreening Information Data Set (OECD/SIDS, 2002) concluded, "Studies in the literature have reported a variety of responses induced by exposure to gaseous formaldehyde, generally beginning in the range of 0.3 to 0.5ppm for eye irritation, the most sensitive end-point.
The dose-response pattern observable in animals depends on interindividual variation in animals rather than in humans, and moreover in the central and least-sensitive part of the animal variation range, not the most-sensitive end that is at issue for additivity to background.
Cholinesterase inhibition is one of the most sensitive toxic end points produced by organophosphate pesticides (U.S. EPA 2006a).
Depressed male sexual behavior was the most sensitive of the end points studied, and we suggest that this ecologically relevant end point be included in avian in vivo testing for neuroendocrine disruptors.
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