Sentence examples for most sensitive developmental from inspiring English sources

In these assays, the exposure start and duration were set to the most sensitive developmental windows related to the assessed endpoints.

The most sensitive developmental parameters included effects on maternal and pup bodyweight with calculated BMDs of 4.0% and 4.3% EtOH, respectively.

Reduced litter size (benchmark dose lower confidence limit (BMDL) 80 mg/kg bw/day) was the most sensitive developmental parameter, with pup relative organ weight effects observed at similar BMDLs, in the absence of maternal toxicity.

Vaccinations, when given at the most sensitive developmental years of childhood, help to promote comprehensive and capable immunity, enabling children to fight off certain diseases.

Therefore, the measured phthalate metabolite levels may not reflect exposure during the most sensitive developmental window, resulting in some degree of exposure misclassification.

Both the VMR and CV showed that the average Arabidopsis transcript was most sensitive to developmental perturbation (Tables 1 and 2).

In this paper we present an analysis of the different changes in gene expression in developing meiotic anthers (the first and most sensitive anther developmental stage) in response to MHS of tolerant and sensitive tomato genotypes.

Studies with chlorpyrifos show that 5HT systems are among the most sensitive to developmental disruption, with adverse effects detectable even when exposures lie below the threshold for inhibition of cholinesterase (Aldridge et al. 2003, 2004, 2005a, 2005b, 2005c; Qiao et al. 2002; Raines et al. 2001).

Neural pathways involving acetylcholine (ACh) appear to be among those most sensitive to developmental disruption by OPs, partly because these agents specifically direct differentiation away from the ACh phenotype (Jameson et al. 2006; Slotkin et al. 2001, 2007a) and also because ACh neurons appear to be more vulnerable to toxic damage (Slotkin 1999, 2004, 2005).

The most sensitive general endpoints of developmental toxicity (i.e., decreased fetal survival and growth) were chosen for modeling.

Fetal life is considered to be the most sensitive stage to the potential developmental and reproductive toxicity of the phthalates, but data on human fetal exposure to phthalates is still scarce [ 9].