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We were reminded of this on hearing about the work of a Japanese geneticist, Dr. Sadao Ichikawa, who has found that a spiderwort hybrid, a roadside wild flower that grows in central Texas, may be one of the most sensitive biological detectors of low-level ionizing radiation.
Benchmark dose (BMD) analysis on gene expression data revealed that Nrf2-mediated antioxidant response and protein ubiquitination were the most sensitive biological pathways that were activated in response to low concentrations of HOCl (< 0.35 mM).
Germination index which combines the measure of seed germination and root growth of seeds is one of the most sensitive biological parameter used to evaluate toxicity and the degree of maturity and stability of vermicompost (Zucconi et al. 1981; Wong et al., 2001; Campitelli and Ceppi 2008).
Our hypothesis is that a mild inhibition of the V-ATPase will reveal the most sensitive biological functions for that enzyme, which will be indicated by genes that first increase transcription in response to the inhibition.
In this context, chloracne is one of the most sensitive biological indicators of occupational or environmental exposure to certain highly toxic halogenated aromatic hydrocarbons.
At the 168 h time point, the most sensitive single gene was dihydrolipoamide dehydrogenase (Dldh) (BMD = 5.96 ng/L) and lipid transport was the most sensitive biological process (11.57 ± 2.54 ng/L) (Table 2).
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Though bacterial expression is sufficient for most purposes, some sensitive biological assays as well as in vivo validation prefer mammalian expression of antibody.
Sensitivity analysis of the RSN component using 2006 land use practices was also conducted and crop yield and N uptake were found to be the most sensitive parameters, followed by biological N2 fixation and the addition of fertilizer N and manure N. Land use scenarios were evaluated to examine if increasing the proportion of biofuel crops grown in Canada would change RSN and IROWC-N appreciably.
Within the overall process, the most sensitive and critical part is the biological process of gas production.
Here, a dose-dependent inhibitory effect of the drug was observed in all four types of CRC cells, with HROC24, like in the biological assays, as the most sensitive cell line.
Third, instead of performing a GO enrichment analysis at each dose level, the analysis by BMDExpress summarized the data by showing which biological processes were the most sensitive to environmental estrogens and provided reference concentrations at which they were affected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com