This particular detection method provides the most sensitive approach for conventional CCB (Colloidal Coomassie Blue) stained gels, which is reflected in a total error of just 5% (RSD%).
It is the most sensitive approach in determining the proportion of hospital deaths that are preventable.
While the living animal assay remains the most sensitive approach, it is costly, slow and associated with legal and ethical constrains.
The most sensitive approach (based on the number of proteins matched) used the SUPFAM MHC class I APD model, the PFAM Ig domain and HMMer2 in fs-mode.
Protein sequence based similarity searches are more sensitive than DNA based searches, and profile searches that take advantage of information on site-specific variation along protein domains are proven to be the most sensitive approach for detecting sequence homology [ 18- 20].
If even short periods of hyperoxia were dangerous, then the highest PaO2 would represent the most sensitive approach to identify patients at risk; conversely, if the overall effect depended on the total amount of excess O2 received, then the mean PaO2 or a time-weighted measure would be a better choice.
We also applied what has been described by Wilke et al. [ 2003] as the most sensitive approach to identify focal cortical dysplasia (FCD); affine registration, non-linear warping using discrete cosine transform with a non-linear cut off of 25 mm, 16 non-linear iterations and default (medium) regularisation, "non-modulated" images.
This radioligand binding assay (RBA) remains the most sensitive quantitative approach to measuring binding parameters in vitro, even in low receptor-expression cells (Rovati 1993; Keen 1995).
Although this bioassay remains the most sensitive detection approach, it is costly, slow (takes days), associated with legal and ethical constraints and is restricted to the CDC along with some state health department laboratories.
Genome sequencing not only represents the most sensitive subtyping approach conceivable, but also provides for specific identification of differences between isolates, which can be used to assess whether differences between two isolates are likely to have occurred within a short time frame or not.
