Sentence examples for most selective compounds from inspiring English sources
Pentamidine and suramin were the most selective compounds identified, illustrating the target selectivity (>1000-fold >1000-foldld be aimed for athate final should of lead development.
Two conventional hydrogen bonds with the hinge seem to decrease selectivity, as some of the most selective compounds either lack both hydrogen bonds or exhibit weaker interactions (e.g., paroxetine and the Takeda compounds for GRK2, and H-1152P foROCK1K1).
The most selective compounds 4l and 4n were further screened for their in vitro cytotoxic activity against MCF-7 and MDA-MB-231 cancer cell lines under hypoxic conditions.
The 3β- 4-methylthiophenyl tropane 7a and its N-(3β- 4-methylthiophenyl tropaned N-allyl analogue 10a are the most selective compounds for the 5-HTT over the NET (NET/5-HTT = 3β- 4-methylthiophenyl tropane
Our results showed that most selective compounds against caspsase-3 bind into the substrate binding cleft acting as competitive inhibitors whereas in caspase-7 they bind close to an allosteric site at the dimer interface but since they are weakly bound their presence would not be affecting enzyme dynamics or function.
The two most selective compounds which exclusively bind to TTR (20b and 22b) are iodinated (Figure 6 and Figure 7).
The most selective compound, 2k, presents a selectivity index value of 6200 and an IC50 of 10 nM against the parasite.
The most selective compound resulted 5a, with a SI of 11.9.
11i was the most selective compound against HDAC6 with IC50 values of 0.020 µM and selective factor of 101.1.
The most selective compound, novel compound 6, has an IC50 of 0.83 ± 0.07 μM and a selectivity of more than 120-fold for AKR1B10/AKR1B1.
In this regard, compound 7-{[4- 4-phenyl-piperazin-1-yl -butyl]-prop-2-ynyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol (7-{[4- 4-phenyl-piperazin-1-yl -butyl]-prop-2-ynyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol quinpirole and was also the most selective compound for the D3 receptor in this series.
