A study last year by Caroline M. Hoxby, an economist at Harvard, ranked colleges by selectivity -- 1 being the most selective, 8 the least.
Compound 6 (Cdk1/2 inhibitor III) was the most selective (18-fold) for PKN2 over PKN1 with only minimal selectivity over PKN3.
At the nation's most selective 193 colleges and universities, affluent students (those from the richest socioeconomic quarter of the population) outnumber economically disadvantaged students (those from the bottom quarter) by 14 to 1.
1400W is considered today the most selective NOS2 inhibitor, as it inhibits NOS2 with 5000- and 200-folds greater potency than NOS3 and NOS1, respectively [20].
As expected, CGP 20712A was the most selective β1-adrenoceptor antagonist, and ICI 118551 was the most selective β2-antagonist.
Among them, SNS-032 (BMS-387032) appears to be the most selective CDK9 inhibitor.
These hypotheses and characterisation of ligand interactions, including those of the most selective FGFR3 ligand FGF8, require further investigation.
One of the most selective NR2A antagonists, PEAQX, has been shown to have a 13 130-fold preference for NR13 130-fold NR1/NR2B recepreference
One of the most selective HMGB1 inhibitors, TSN IIA-SS, has already been used in China as a medicine for patients with cardiovascular disorders (Ref. 138).
However, the most selective DDR1 kinase inhibitor DDR1-IN-1 does not seem to have significant antiproliferation effects on DDR1 deregulated cancer cell lines, whereas the multitarget inhibitor DDR1-IN-2 shows a more profound antigrowth effect.
