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Focusing on DKK1, one of the most robustly bound RBM47 target transcripts identified by HITS-CLIP, we investigated the possible role of RBM47 as a modulator of mRNA abundance.
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Immunoprecipitation studies confirmed that the wild-type WNK4 robustly bound to KLHL3, but interaction with either disease-causing WNK4 mutant tested was strikingly impaired.
You can't even say that the brilliant Willis Burks II and Stephen McKinley Henderson are outstanding, because the nine-member cast gives you ensemble acting at its most robustly realistic.
"I did watch, and occasionally unscrewed a spark plug," he recalled, but the expertise he developed most robustly was "ferrying in cherry Cokes from the nearby restaurant".
The results show that the proposed approach performs most robustly in comparison with the others.
These results suggest that pharmacotherapies most robustly dampened amygdala functioning in smokers appearing susceptible to abstinence-induced effects.
The leech example highlights a critical aspect of co-option: it is most robustly studied within a phylogenetic framework because it is inherently historical.
Israel has one of the most robustly militarized borders, with an above-ground security barrier already in place and its Iron Dome defense system protecting the skies.
The wound signature is most robustly recapitulated by the overexpression of both MYC and CSN5.
Second, we re-date the Austronesian language phylogenies using only the most robustly attested historical information.
TIMP-1 level was most robustly related to risk of stroke.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com