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Additionally, evaluation efforts undertaken in the most robust studies leveraged large care systems and strong quasi-experimental evaluation designs.
The largest, most robust studies found no dose response and no statistically significant increase in use of 2,4-D and NHL.
The effect of oral contraceptives on mental health, including depression and mood changes, is not well understood but some of the most robust studies actually suggest a small but protective effect.
The 2 cohort studies (ie, the most robust studies) clearly showed reduced MRSA colonization and/or infection, both individually and when combined, whereas the cross-sectional and case-control studies showed no effect.
Though simulation is powerful learning activity, particularly for teamwork competencies, some of the most robust studies published since these previous reviews were completed did not use elaborate simulation methods, but still achieved significant reductions in both mortality and morbidity.
In other situations, however, including such a wide range of data in the same matrix may run the risk of concealing, or even distorting, the most important and valid inferences which could be derived from a subset of the most robust studies.
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It is not the most robust study: 40 people copied numbers from a telephone directory for 15 minutes and then had to come up with different uses for a pair of polystyrene cups.
The most robust study (Kyle et al, 1992) reported the incidence to be 8·9 per million person years.
Thus, using the most robust study quality evidence available, it could be hypothesised that PAD is present in approximately one-third of general inpatient populations.
This is therefore the largest and most robust study to date of the relationship between TNFi exposure and the risk of solid cancer in patients with RA.
However, the most robust study in West Africa by Gureje et al found no correlation between any demographic variable, including urban, semi rural and rural dwelling [ 10].
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