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Finally, we review future directions, including the need to better characterize interperson and intraperson variation in the metabolome, pool existing data sets to identify the most robust signals, and capitalize on the discovery potential of emerging nontargeted methods.

Also, we emphasize that this cluster was present in almost all subalignments; it is one of the most robust signals in the CS dataset.

Our data suggests that 20-HETE generated by ozone may represent one of the earliest and most robust signals promoting ozone-induced AHR.

To overcome these limitations, Li and colleagues used a novel multiple survival screening (MSS) algorithm, designed to extract the most robust signals from the data [ 11].

Under any scenario of increasing greenhouse gas concentrations, the most robust signals of future climate changes are more severe heat-related extremes, such as increases in the length, frequency, and intensity of heat waves during the course of the current century (Meehl et al. 2007b; Meehl and Tebaldi 2004; Stocker et al. 1992; Stocker and Raible 2005; Tebaldi et al. 2006).

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The most robust signal remains after being filtered through the two independent datasets.

Lead's inhibition of BMP-2 Smad signaling "represents the most robust signaling effect identified to date in a skeletal cell type with regard to a candidate mechanism of [lead] toxicity," the authors state.

Overall, the potent inhibition of BMP-2 induced BMP-2 inducednaling by Pb represignaling most robyst signaling effect identified to date in a skeletal cell tyPb with representsa candidathemostanism of Pb toxicity.

In dose-response preliminary in vitro studies, 30 μM Cur demonstrated the most robust HSP25 signaling activation and was used for all experiments.

Nevertheless, it is the anterior hippocampus that shows the most robust BOLD signal and the most pronounced lesion effect, both in our patient sample and in previous TLE samples [ 20].

It is shown by numerical examples that the detector derived according to the one-step design procedure has higher probability of detection than its counterparts in the absence of signal mismatch, while the detector devised according to the two-step design procedure is most robust to the signal mismatch.

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