LAS biclustering of 738 ECM-related genes identified Chinese and Caucasian ECM3 clusters (Fig. 3A and B), whose gene content and stability parameters (Tables S7 and S8) were comparable to those of ECM3 clusters described in 6 independent datasets 26, confirming ECM3 as the most robust ECM cluster in Caucasian and Chinese breast cancers.
We have identified QTL mapped consistently across multiple coppice cycles in poplar grown as SRC and have defined the five most robust QTL clusters as Poplar Biomass Loci 1 5.
MIPS clusters, which consist of densely interconnected clusters, are most robust to edge noise effects.
Although the connectivity of the protein clusters depends on the functional role of the cluster, we could conclude that a connectivity of 25% (compared to 0%, 50 %, 75 % and 100 yielded the most robust and functionally relevant protein clusters (data not shown).
Most of the robust clusters relating to the modern branches of the economy are concentrated in the larger urban areas of Sweden, though in some cases, also in other larger regional urban centres.
The protein cluster showing the most robust positive association with BMI contained a number of pro-inflammatory proteins of which several are involved in the acute phase response, such as CRP, IL-6, C3 and SAP.
Following treatment with declustering drugs, the interphase Golgi complex fragmented, and the distribution of Golgi fragments closely mimicked scattering of the centrosomal cluster, with the most robust effect seen with RedBr-Nos and Griseofulvin.
As has been previously described for the n-ELAV proteins (Ince-Dunn et al., 2012), identification of the most robust binding through increased stringency of cluster definition led to an increase in proportional binding in 3′UTR regions.
Figure 5A presents the numerical results obtained while considering the noise as a single additional cluster: DBC454 is clearly the most robust method, but ESPRIT-Tree also achieves a good robustness for some intermediate tree-depth values.
