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Further analysis with an additional 50 markers showed the most robust association on chromosome 7 (Figure S2, Panel C).
Together, these results suggest a selective association of candidate gene polymorphisms with chemokine levels, with the most robust association of a CXCR1 polymorphism with CXCL-8 concentrations in those with ASB.
Not unexpectedly, education had the most robust association with knowledge.
Overall, the ambient two-pollutant models show the most robust association for NO2 and EC.
The most robust association was with oral candidiasis (75% of bootstraps) and with CRF19_cpx (62% of bootstraps).
For personal two-pollutant models, the most robust association was for EC, followed by NO2, PM2.5, and then OC.
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Moreover, we were able to confirm the most robust associations in a second, even smaller population consisting of subjects from a different age group.
More refined exposure models produced the most robust associations.
To determine the genes with the most robust associations we used several filtering criteria.
Two of the genes that have shown the most robust associations are NRAMP1 and VDR.
The effects were sensitive to the method of exposure estimation, and more refined exposure models produced the most robust associations.
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