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This meta-analysis was based on the evidence from the two most rigorous trials applied to vertebroplasty to date.
One of the most rigorous trials was of the multi-component MEMA kwa Vijana adolescent sexual health programme, which showed improvements in knowledge and reported attitudes and behaviour, but none in biological outcomes.
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The most rigorous trial so far was by Hagen et al, 14 who randomised 447 women with symptomatic stage 1-3 prolapse to pelvic floor muscle training or a lifestyle leaflet.
This analysis was restricted to the most methodologically rigorous trials, with the caveat that many of these trials were conducted many decades ago (and most papers were published before 1973), in an era with different standards for statistical and methodological rigor.
Even the most rigorous clinical trials won't help them choose.
For the documentary they undergo two days of tests, one with MDMA and one with a placebo (clearly what might make good television doesn't make the most rigorous of trials).
15 Most variants of CBT for treating gambling disorders have shown to be clinically beneficial compared with no treatment, and the most rigorous clinical trials have comprised a combined cognitive-behavioural approach.
The most rigorous clinical trials blind both clinicians and participants as to who is receiving the intervention in question; so that any effects may be attributed to the intervention itself.
The generalisability of the available evidence for efficacy of BPTs to LMIC settings may be limited by the narrow representativeness of the study populations in the most rigorous efficacy trials, most of which were drawn from high-income (mostly English speaking) countries.
The limited information available on the nature of the transplanted cells (Poltavtseva et al, 2003) makes it difficult to predict whether this event is a consequence of inadequate cell characterization or whether it may re-occur in the future, even in the most rigorous and controlled trials.
Speaking from a meeting of the American Society of Clinical Oncology in Chicago, Doroshow called the biggest of the trials -- the National Cancer Institute's Molecular Analysis for Therapy Choice, or NCI-MATCH for short -- "the largest, most rigorous physician-run oncology trial that's ever been attempted".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com