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To our knowledge, the three validated genes shown here were found to have the most restricted expression patterns ever seen for melanoma and we presume that future functional studies of these genes will shed new light on melanocyte and melanoma biology.
PDF-Gal4 was the Gal4 line with the most restricted expression pattern for those neurons.
K20 is the simple-epithelial keratin with the most restricted expression pattern.
Zebrafish S100Z (Fig 14A E) is the gene with the spatially most restricted expression pattern in the larvae.
In contrast, ASV derived from VEGFR3 had the most restricted expression, and were observed only in a few normal tissues and cancer cell lines.
It has the most restricted expression pattern and, except for a few non-chondrogenic tissues, is secreted only in hyaline cartilage and during developmental stages of chondrocytes [ 30].
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While HD transcription factors represent a large family of proteins with over 100 members, most display restricted expression patterns that are predictive of function.
While considerably increased, contacts of Hoxd13 with the telomeric part of the cluster were however weak, most likely reflecting the restricted expression of Hoxd13 at this stage, in a small subset of the dissected cells.
We did not observe repression of hepatic lipase in our experiments, most probably due to its restricted expression on the surface of hepatocytes.
However, in contrast with the restricted expression of most other Siglec genes to the haematopoietic and immune systems, Siglec-H is also transcribed at high levels in postnatal brain.
An alternative to the approach just outlined picks out the GAL4 line(s) with a given phenotype that have the most restricted overlap with fru M expression.
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