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These data indicate that transfected miRNAs bound to their target MREs and repressed the expression of luciferase, with the most responsive targets derived from the 3'-UTR of Wnt7a and Gpr88.
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However more investigations are required to confirm the impact of WBV on bone mass and to identify the most efficient vibration parameters and the most responsive target population [29 33].
The uterus is one of the most prominent estrogenic responsive target tissues, predominantly expressing ERα (Couse et al. 1997).
With the prediction of hundreds of conserved targets for most mammalian miRNAs (and even more nonconserved targets), knowing which targets are expected to be most responsive to each miRNA provides important information for both large-scale network analyses and detailed experimental follow-up.
These four miRNA families were chosen because their predicted targets were the most responsive to knockdown of the 25 miRNAs.
"The people who tend to be most responsive to information may be those we least aim to target".
Here they recommend a departure from simplicity, urging governments to use the tax system to target incentives to those who will be most responsive.
Behind the scenes, he says Pontiflex has developed its own set of algorithms for targeting the audience that will be the most responsive to an ad.
By targeting the messages to subgroups known to be most responsive, program costs could be reduced by over 50% with only a 20% reduction in the treatment effect.
"Rebates are targeted tax cuts to the consumer who is most responsive to your product.
It seems that the RELA and RELB genes may be the most the SP1-responsive targets; details are presented in Table 2.
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