A selection of the most representative lines were then further characterized by genome-wide transcriptome analyses and systems biology to identify key pathways, signaling molecules, gene networks, and putative drug targets critical for growth and invasion of malignant PrCa cells.
We applied the UBC molecular classifier based on gene expression defined by Sjodahl et al [ 12] to identify lines most representative of the taxonomical groups proposed.
The basal keratins KRT5, KRT6A-C, KRT13, KRT14, and KRT17 represent the most representative genes for round spheroids, characteristic for the basal-like phenotype of in-vitro immortalized lines and normal prostate-epithelial cells.
As discussed in [17], a scene with vanishing line should be the most representative and easy to manipulate.
Given that most lines exhibited severe fertility defects, one representative line (#11) was chosen and characterized in detail.
Advanced backcross populations have been developed and used, with near-isogenic lines (NILs) being the most representative type.
Interestingly, in pleural mesothelioma, the most representative asbestos fibers are ultrathin ones [ 3], in line with a lower steric hindrance, compared to longer fibers, to be dragged down water fluxes.
Political debate along party lines has thus become a characteristic feature of most representative systems of government.
The contradictions along the line converge near the center, in the city that is arguably the most representative of our new and confusing economy.
Furthermore, it has been hypothesized that bladder inflammation and neoplastic cell growth, the two most representative pathological conditions of the lower urinary tract, may arise from a primary defective urothelial lining.
