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Benzoylecgonine, as a main urinary metabolite of cocaine in human, is so far the most reliable marker of cocaine consumption.
Urinary isoprostane iPF2α-III is a new marker reflecting oxidative stress; it has emerged as the most reliable marker of oxidative stress status in vivo.
However, the expression of 4-hydroxy-2-nonenal (4-HNE), the most reliable marker of lipid peroxidation, has not been studied, and the antioxidative effects of carvedilol have not been investigated in the setting of acute viral myocarditis.
Receiver operating characteristic curves (ROC) were generated to evaluate the predictive ability of the change of PCT (ΔPCT = PCT before tracheostomy - PCT 12-24 hour after tracheostomy) for perioperative complications and showed ΔPCT was a most reliable marker with area under the ROC curve of 0.99.
But then, in each patient, there was an abrupt burst of brain activity lasting about a minute or more which correlated with gamma synchrony EEG, the most reliable marker of conscious awareness.
Although FoxP3 is still regarded as the most reliable marker of Tregs in human cancer [82], [83], it can also be expressed by epithelial tumor cells [84]-[86 [84]-[86vitro activated CD4+ and CD8+ T cells [87]-[95].
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Indeed, as the authors point out, "Mutual eye gaze is one of the most reliable markers of love between couples".
To date, probably the most reliable markers to identify most mouse satellite cells is either immunostaining for Pax7 [7], or detecting β-gal from the targeted allele in the Myf5nlacz/+ mouse [9].
This is currently considered to be one of the most reliable markers of monocyte-derived cells.
Hence, integrin β3 is emerging as one of the most reliable markers to diagnose disease progression in prostate cancer patients.
However, the development of chromatin immunoprecipitation and usage of CENH3 variants as the most reliable markers of active centromeres enabled high-resolution DNA mapping of interacting sequences.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com