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An important issue concerning expression profiling in these disorders in man is the lack of the most relevant tissue, i.e. the brain, for study.
We decided to focus on studies of the brain because this is arguably the most relevant tissue for a psychiatric disorder like BP.
Although convenient, use of blood is not likely the most relevant tissue for investigating the effects of birth characteristics on developmental phenotypes.
This may reflect residual confounding because adjustment for weight or BMI does not fully cover the adjustment for fat, the most relevant tissue.
DNA methylation patterns vary widely across the genome by developmental stage and by tissue type [ 1], making study design a challenge when the most relevant tissue is not accessible from living humans.
Approaches that improve transient targeting of gene expression in intact human islets are needed in order to effectively perturb intracellular pathways to achieve biological effects in the most relevant tissue contexts.
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A ranked structure of the most relevant tissues, diseases, and compounds was thus pre-computed for each signature.
For ALT, the most relevant tissues in this analysis are the thyroid and gonad (Tables 2 and 4).
Although the most relevant tissues, like brain, may be obtained from non-human subjects, animal models often fail to adequately reflect the range of symptoms seen in humans.
Nevertheless, with peri-articular bone as the most relevant background tissue, mean arthritic-to-ipsilateral bone ratios of [F]fluoro-PEG-folate (1.64 ± 0.15) were significantly higher than those of (R -[C]PK11195 (1.14 ± 0.18, P <0.05).
The zebrafish xenotransplantation model can also be applied to drug screening and rivals transgenic approaches by allowing the direct evaluation of the most clinically relevant tissue, namely human cell lines or primary samples.
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