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In the direct measurement the most relevant therapy characteristics were "drug does not affect or not affect appearance much", "self-application of the drug is possible" and "rarely occurring longer periods of nausea and diarrhea".
We aimed to build a multivariable model including the best general ICU score, the best biological variable of hepatic failure, and the most relevant therapy performed at ICU admission.
The most relevant therapy characteristics represented by mean assessments of more than 90 points were: – Self-application of the drug is possible, – Drug has very high efficacy, – Long term (hidden) side effects are unlikely.
In the direct measurement the most relevant therapy characteristics were "Self-application of the drug (at home or on-the-go) possible", "Drug has very high efficacy (reduction of viral load)" and "Long term (hidden) side-effects (e.g. organ damage) is unlikely".
In the direct measurement the most relevant therapy characteristics were "Self-application of the drug (at home or on-the-go) possible", "Drug has very high efficacy (reduction of viral load)" and "Long term (hidden) damage (e.g. organ damage) is unlikely".
The ultimate goal of diagnostics in CSF is to detect the earliest meaningful sign of neoplastic presence in the CSF to enable clinicians to react with the most relevant therapy.
Similar(54)
These concerns are discussed herein in the context of the most relevant gene therapy studies conducted so far in HIV/AIDS.
Is it most relevant to provide therapy in a high- frequency fashion, so that high therapy frequency, a maximum of the number of treatment hours per time interval, is achieved?
The statistical analyses allowed us to identify the best score of organ failures, the best marker of liver failure, and the most relevant organ replacement therapy to predict in-ICU mortality.
The equine model has critical size defects up to 9 mm, cartilage mean thickness of 2.0 3.0 mm and a vertically loaded stifle joint during gait, and so is beneficial for translatable cartilage studies and especially partial thickness defects which are the most relevant to human therapy (ASTM F2451 05 2010; Ahern et al. 2009; Malda et al. 2012).
It is therefore timely to consider the role of mouse models in addressing aspects of disease pathogenesis that are most relevant to SMA therapy.
Related(20)
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