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In addition, a memory management strategy based on Kullback Leibler divergence is proposed to rank and select the most relevant target and non-target reference samples to be stored in memory as the ensembles evolves.
However a larger validation study is warranted to better define the most relevant target genes.
On the other hand, in breast cancer cells the most relevant target of miR-17 is not E2F1, but AIB1.
We also looked at the completeness of coverage of the non-repeated parts of the target region, as these make up the biologically most relevant target.
This strengthens the idea that XIAP is the most relevant target of BV6 in the enhancement of TRAIL-induced cell death.
Our results indicate that the soluble nuclear Cdk2 fraction is the most relevant target of TGF-β and rapamycin with respect to Rb dephosphorylation and cell cycle arrest induced by TGF-β and rapamycin.
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The oxidative degradation of lignin under totally chlorine free conditions is one of the most relevant targets for the design of environmental friendly pulping and bleaching industrial processes.
With the near completion of the human genome sequencing, bioinformatics has established itself as an essential tool in target discovery and the in silico analysis of gene expression and gene function are now an integral part of it, facilitating the selection of the most relevant targets for a disease under study.
Given our experimental approach using a cocktail of protease inhibitors, it also remains to be determined exactly what proteases are involved, how they interact with each other, what S. aureus proteins are the most relevant targets, and what role these targets play in biofilm formation.
Therapists are instructed to keep the duration of sessions as constant as possible, selecting only the most relevant targets.
We present for the first time pathway analysis results on asbestos-associated lung cancer, providing important insight into the most relevant targets for future research.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com