Importantly, in the present study we were able to perform additional analysis for the clinically most relevant polyp size threshold on both a per patient and a per polyp basis.
If surface area is indeed the most relevant parameter regarding size, this also could suggest some hypotheses for the mechanism of AuNP effects, namely, that the interaction is with the ligand attached to the core surface or the core surface itself.
In order to extend the work of the CISNET, we chose a simple approach based on the most relevant prognostic parameters: tumour size and axillary lymph node involvement.
The frequency of beneficial mutations, and thus the intensity of interference, depends on several factors, among which some of the most relevant are the population size, the error rate, and the degree of adaptation of the population [ 11, 12].
The strengths of this study include the examination of a geographically and demographically diverse population of U.S. women who participated in a large randomized trial of postmenopausal hormone therapy, the rigor with which VTE outcomes were ascertained, and the analysis of PM10 as well as PM2.5, the particle size most relevant to regulatory efforts in the United States.
Of the organisms for which an essential gene set has been identified, H. influenzae, F. tularensis, Acinetobacter, M. tuberculosis, Salmonella Typhimurium, S. aureus and B. thetaiotaomicron are the most relevant based on genome size, ecological niche and genetic relatedness to P. gingivalis.
New methods have been developed to produce NPs with increased control of NP size between 10 and 200 nm, a size range most relevant to physical and biochemical targeting through both intravascular and site-specific deliveries.
For the public health view the actual effect sizes are most relevant, while for the sponsor view, the observed effect sizes as considered in Posch and Bauer (2013) may be more important.
This was most relevant for reporting of sample size calculations and the number of participants in each study arm.
