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Collection was done during daytime, shown previously to be the most relevant period for plant-parasitoid communication (parasitoids do not forage at night [23]).
In such studies, residential addresses are available only at birth, not in the first trimester of pregnancy, the most relevant period for causation of congenital anomalies (Moore and Persaud 1998).
Pearson's correlations between annual mean of averaged daily value for each window and annual mean laying dates were used to determine the most relevant period for each environmental variable.
As research continues to develop our understanding of the physiologic pathways through which air pollution affects risk, future work may examine alternate model structures that incorporate this information, such as the most relevant period of exposure for the heat index or related weather variables.
The three exposure metrics estimated at the birth address for each case and control were time averaged across monthly estimates for the duration of the pregnancy (assumed to be nine months) because exposures in utero might be the most relevant period for early onset childhood leukaemia 22 (when the birth occurred after the 15th of the month, the birth month was included in the nine month period).
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In our study the first and second trimester seemed to be the most relevant periods for NO2 exposure.
A better understanding of basic mechanisms at different time points in life would guide genetic epidemiology studies in selecting environmental exposures that are more likely to affect epigenetic processes, identify the most relevant periods of exposure, identify biomarkers of exposure, and suggest biological intermediates to study.
These observations being independent of the study designs applied suggest that the post-weaning period, included in all designs, is the most relevant sensitive period for inducing 4MA mediated developmental immunotoxicity.
In a case-control study of sporadic Salmonella Enteritidis infections, Molbak compared food exposure data obtained for an exposure window corresponding with the maximum incubation period (7 days) to food exposure data for an exposure window corresponding to the most relevant incubation period (1 day) [ 36].
We also investigated receipt of aspirin prescriptions in the most relevant exposure period; that is, following diagnosis when treatments may be implemented to prevent cancer progression.
It is not known which stage in life, if any, is the most relevant time period during which dietary intake influences breast densities in later life, but there was low tracking of childhood calcium intake into adulthood.
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