Sentence examples for most relevant mediators from inspiring English sources

This unexpected result could be related to the regulation of NO production since peroxynitrite seems to be one of the most relevant mediators of sepsis-induced AKI [13, 20, 21].

TNF-α, IL-6 and IL-17 are being described as some of the most relevant mediators in SA immunopathogenesis [ 26, 33].

Several different receptor-associated proteins have been described for the AT1 receptor, which is the most relevant mediator of the renin angiotensin system (RAS).

Our study revealed that attaining to the antihypertensive drug therapy advocated by the Brazilian guidelines significantly attenuates serum levels of the most relevant proinflammatory mediators implicated in the inflammaging of the human biology, with undetectable effects on other mediators involved to a lesser extent in the phenomenon.

For the explanation of the beneficial effect of pre-conditioning, the level of pro-inflammatory mediators directly before the onset of ischemia seems to be most relevant.

It is preferable to test several theoretically relevant mediators between maltreatment and NSSI simultaneously in a multiple mediation model because the mediators often co-occur [ 27].

The most relevant differences were detected in relation to IL-1 β and IL6, these two cytokines being important proinflammatory mediators involved in DEs [ 31– 33, 44].

The renin-angiotensin-aldosterone system (RAAS) is a major mediator of progressive renal injury in CKD, with angiotensin II (AngII) and aldosterone (Aldo) being the most relevant RAAS components [ 11, 12].

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