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In other words, only the absolute concentrations were used to identify the most relevant markers.
Next, applying a penalized least-squares regression technique with an L1-type penalty to the expression data (see Materials and Methods) it was possible to identify four p53 target genes among the 122 genes studied as the most relevant markers for predicting the proliferating or arrested phenotype of each cellular condition.
Given the large data set, the analyses described here focus on the median cutoff and continuous scale for the GBM method to identify the most relevant markers overall.
In this study, we assessed the capacity of MMP1, one of the most relevant markers, to detect HNSCC tumor cells in saliva cells; this provided information on its utility as a non invasive diagnostic marker.
To assess the usefulness of combining several virulence markers, we used logistic regression with a backward procedure to select the most relevant markers; only markers for which area under the ROC curve was >0.80 were initially entered as explanatory variables in the regression analysis.
See related research by Vaz-Luis et al., http://breast-cancer-research.com/content/14/5/R129 In this era of personalized medicine and emphasis on identifying prognostic and predictive molecular profiles, breast tumor testing for hormone receptor status and HER2 remain the most relevant markers for practice.
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Its genomic amplification, occurring in about 20 25% of NB cases, is the most relevant marker of poor outcome in humans.
At present, the most relevant marker in breast cancer diagnostics is the lymph-node status of the patient.
Formation and accumulation of O6-alkylguanine and O4-alkylthymine in human tissues is possibly the most relevant marker for cancer risk.
Given the natural involution of breast with aging [ 75], breast density measured at 25 29 years old, as in our study, might be the most relevant marker of the effect of adolescent sex hormones on the breasts, if any.
In addition, BNP, a peptide hormone released from the cardiac ventricles in response to pressure and volume overload, is among the most relevant molecular markers of cardiac hypertrophy [ 48].
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