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In the long-term studies the rich description of the possibilities (criteria 1 and 3) is the asset but also the most relevant lines of development (criterion 4).
We utilize this information in three ways: to evaluate which move is best after we are done expanding, to allocate additional thinking time to moves where additional time is most relevant to game outcome, and, perhaps most importantly, to expand the tree along the most relevant lines.
Furthermore, to effectively address risk assessments which may initiate from a variety of concerns, the tiered scheme must allow for a non-linear approach, so as to allow the most relevant lines of evidence to be brought forward.
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For this purpose we used CHO-K1 and HEK293 cells - the most relevant cell lines for protein production.
The NB4 cells appear therefore to be the most relevant cell line to study cAMP effects on anthracycline-induced acute myeloid leukemic blast death.
HEp-2 cells will be used for all MIC determinations as they are the most relevant immortalised cell line (cervical), are widely used, and have previously been shown to have consistent performance in MIC assays when compared to other cell lines [ 35].
Focusing on CRC cell lines, we validated this approach for three different fields of application, i.e. the identification of cell lines most relevant for modeling and investigating tumor cell invasion, drug absorption and/or transport, and response to chemotherapy.
The present analysis suggests that as more mechanistically relevant HTS data are generated and a greater number of compounds are screened, computational toxicology tools could be used to select most relevant HTS assays (cell lines and/or measurements) and prioritize chemical agents for screening.
The most relevant conditions are cell line, dose, and treatment duration.
Fig. 3 Marginal density distributions of coefficient estimates of the six most relevant explanatory variables: the blue line represents the marginal density; conditional expected values (Cond.EV) are displayed in red solid line, the median in green solid line.
Along this line, the most relevant result for our research comes from [20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com