Clearly, they provide the most clinically relevant indication of intervention effects, but it is important to realise that symptoms by themselves may not necessarily indicate altered immune function because other non-immune system-mediated mechanisms may be responsible for the changes in symptom scores.
It is possible that just some weak signals give indications of the most relevant futures.
Ecological indication is the most relevant way to approximate the implications of cause effect networks which go beyond spatio-temporal extents of direct experimental accessibility.
We did not include in our review studies which compared the effect of pictures of nature versus pictures of more synthetic environments, however, such studies have been conducted [ 52, 53], and this approach may prove useful in providing some indication of the most relevant environmental attributes.
From studies that reported risks over two or more different durations of follow-up (from a fixed timepoint of baseline RNA or CD4 measurement) [30], [31], we included the estimate for the shortest follow-up duration, as short-term prognostic indications are likely to be most relevant in patient management.
However, in literature-based discovery there are many distinct scenarios and in some situations a great number of indications may not reveal the most relevant new interactions.
For these reasons, some guidelines have been developed in recent years with recommendations that include indications for MSK-US examination, which anatomical part or structure to evaluate, or the most relevant clinical conditions for which MSK-US is indicated [1, 11, 12, 13, 14].
Adherence coverage is arguably the most relevant measure for interpreting trial results, as it provides an indication of whether sufficient study medication was taken to expect a biological response.
Comparing our results with a targeted siRNA screen to those of genome scale screens reveals that although the genome scale screens all identified DNA repair factors, there was no overlap in the specific DNA repair factors identified, and no indication of which DNA repair pathway(s) may be most relevant for HIV replication.
