The formation of bladder calculi was identified as the most relevant end point, and because the calculi formation is dose-dependent or local-concentration dependant, with no signs of significant accumulation, the subchronic studies in rats serve as the basis for the risk assessment.
The increasing need of new markers for prediction of response to chemotherapy and long-term PFS (the most relevant end point for TGCT patients in prognostic factor analyses), and the scarce data concerning the expression and significance of MDR-related proteins in TGCT, prompted us to initiate this study.
With the noticeable decline in the number of embryos transferred, the cumulative delivery rate per started cycle may be a most relevant end-point for ART (Supplementary data, Table SXVIII).
However, median PFS and OS, in contrast to disease control and quality of life, may not be the most relevant end-points for trials conducted in patients with refractory or resistant ovarian cancer.
There is no doubt that all-cause death is commonly accepted as the most relevant outcome end point.
For human and mouse, however, 3P-seq data were available for only a small fraction of tissues/cell types that might be most relevant for end users, and thus results from all 3P-seq datasets available for each species were combined to generate a meta 3′-UTR isoform profile for each representative ORF.
We considered the degree of change in BuChE to be the most biologically relevant end point because of wide interindividual variability in baseline BuChE activity (Cocker et al. 2002; Sidell and Kaminskis 1975).
By refusing to be cowed and back down from the record company, he would become a hero all over again, and within short order he was back to making music, his most relevant since the end of the 70s.
Our review focused on the a) consistency, strength/weaknesses, and biological plausibility of findings, b) identification of the most useful and relevant end points in experimental animals and mechanistic studies, and c) identification of data gaps and areas for future evaluation/research.
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Primary human fibroblasts were chosen for the cell invasion tests, as these were considered the most relevant for the intended end application of connective tissue regeneration.
