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Although we do not suggest S BET as a "universal" dose metric (chemistry, charge, etc., are also relevant), we conclude that for the dose metric examined here, S BET is the most relevant dose parameter.
If there was some overlap between the clinical studies comprising PIPs for different conditions, we recorded for each PIP only the most relevant dose investigation study(s), where 'most relevant' meant that studies conducted in a much broader population were not counted.
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16 Dapagliflozin doses of 2.5, 5, 10, 20, and 50 mg have been studied in Phase III studies; however, only the results the of 5 mg and 10 mg doses will be presented as they are the most relevant doses and the ones most likely to be used clinically.
The most relevant conditions are cell line, dose, and treatment duration.
The aim of this prospective study was to perform a workplace dosimetry study only focused on 18F-FDG preparation, in view of defining the most relevant position of dosimeter for extremity dose measurement in the targetted manipulation.
The doses of tiotropium were chosen to provide a robust evaluation of the most relevant part of its dose response curve and the highest dose included 5 µg is its licensed dose in the Respimat® inhaler as monotherapy.
A combination of in vitro and in vivo studies with relevant dose levels will be most useful in identifying the potential hazards of NPs, and a thorough discussion and justification of selected dose levels should be mandatory.
Again, the focus was on associations with blood lead levels, and there was little formal discussion about which lead biomarker was most relevant to hypotheses about how cumulative lead dose may influence cognitive function.
Together with the known involvement of the immune system in cardiovascular disease (Danesh et al. 2002; Ridker 1998; Whincup et al. 2000), these results suggest that whole-body or bone-marrow dose might be the most relevant to radiation effects.
In low doses, which are the most relevant to human use, caffeine effects are exerted by antagonizing brain adenosine A1 and A2A receptors with secondary effects on dopaminergic neurotransmission [1].
Because almost all human BPA exposure is oral (during episodic eating/drinking), dosed feed is the most relevant exposure route.
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