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Double-strand breaks (DSBs) of nuclear DNA, which are mediated by ROS, have been considered as the most relevant biological effect of IR40.
Based on the most widely used methods and/or the most relevant biological endpoints, we have provided some general recommendations on the use of the selected approaches which would the most closely mimic realistic exposure scenarios as well as enabling to yield fast, reliable and reproducible data on the nanomaterial-cell response in vitro.
An ingenious combination of plasmonic nanomaterials and one of the most relevant biological systems, deoxyribonucleic acid (DNA) is achieved by bioconjugating gold nanorods (GNRs) with DNA via electrostatic interaction between positively charged GNRs and negatively charged short DNA.
Enrichment analysis was conducted across three GeneGo curated ontologies along with Gene Ontology [73] to provide a quantitative analysis of the most relevant biological functions represented by the data.
These data suggest that integrative analysis provides a superior platform for hypothesis-generating experiments and potentially greater accuracy in detecting the most relevant biological processes that distinguish different tumors from each other.
The strong similarities that the process of vocal imitation through which songbirds learn their vocalizations presents with the mechanisms underlying the ontogeny of human language have been known for long [9] [11], and they have made songbirds the most relevant biological model to understand language acquisition and its neural correlates [54], [55].
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We used a stringent gene-shaving strategy coupled with knowledge-based analyses to uncover changes in gene expression most relevant to biological responses.
A GES list including most of relevant biological pathways in breast cancer will certainly help to gain more insight into biological systems involved in this disease and will provide a framework to develop rational therapeutic strategies based on meaningful subtyping.
In the present work we analysed the prognostic influence of the most relevant clinico-biological characteristics of HD in a consecutive series of 137 patients diagnosed and treated in a single institution.
In particular, these experiments do not allow one to study completely the non-linear regime (strain typically larger than 10%) that is most relevant in many biological situations (single cell or tissue deformation).
We examined most relevant genes and biological pathways associated with life histories (Figs 5 and S13).
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