While recent biomedical interventions - like male-circumcision [25], the development of a vaccine [26], microbicides [27] and pre-exposure chemoprophylaxis [28] – constitute important advances, they are going to be most successful when juxtaposed with relevant behavioral and structural changes [24].
Within the social behavioral domain, which is most relevant to the symptomatology of autism, the first study to examine behaviors in Nrxn1α KO mice found impaired nest building ability (Etherton et al., 2009), which was interpreted as relevant to social and/or parental behaviors.
Starting these studies with animal models with direct etiological validity should tell us which behavioral constructs are really most relevant to human psychopathology, even if the effects manifest differently on the surface.
Specifically, we treat text-based descriptions of crime compiled by reporting police officers as a record of some fraction of the behavioral and situational factors deemed most relevant to that crime.
Because the exposure-based treatment mainly targets excessive avoidance and control behaviors, the VSI may not measure the behavioral aspects of GSA that are most relevant for prediction of outcome of this treatment.
However, the behavioral profiles of the SHR in the most relevant drug addiction assay, the self-administration (SA) paradigm [ 12] and in another animal model of addiction, the conditioned place preference (CPP) protocol [ 16] are not completely known.
Which is the most relevant number?
Mathematics is the most relevant of subjects.
The other solution is to focus on relevant behavioral measures, both in the past and in the future.
Learn to extract the most relevant details from previous experience, minimising what's not relevant.
