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As depicted by the figure 3 and 4, a very distinct anatomical distribution was found for most regulated genes by the treatment combining RU486 to LPS.
During ovarian follicle atresia, most regulated genes fall in the cellular metabolism, establishment of localization, and cellular component organization attributes.
Wurmbach et al. [ 21] have shown that most regulated genes in brain tissues in mouse fall within this range.
Supplemental Tables S1 S3 list the 100 most regulated genes by H2O2 in undifferentiated and/or decidual HESCs.
Most regulated genes were involved in metabolic processes, probably reflecting metabolic adaptation to nasal mucosa explants, of fatty acid biosynthesis, oxidative phosphorylation, and of phenylalanine, tyrosine and tryptophan biosynthesis (Additional file 1: Table S2).
Within the 10% most regulated genes, including both downregulated and upregulated groups, we selected genes that were involved in various regulated biological functions (metabolism, muscle-system/contraction and apoptosis), the GIMAP4 family member, the transcription factors MYF6 and HIF1A and other potential regulators such as TOP2A and CCDC80, and THY1.
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Of the most differentially regulated genes, 30 genes demonstrated up-regulation and 100 genes were down-regulated.
The most striking pattern seems to be that most developmentally regulated genes are result of lineage-specific duplications.
Of the most differentially regulated genes (Table 5), Slc9a3r1 is the most likely to have roles in osteoblast proliferation and/or differentiation.
The p-values range from 0.000001 to 0.000214 for the most up regulated genes and from 0.000004 to 0.000203 for the most down regulated genes.
The fold change values range from 47 to 6.3 for the most up regulated genes and from −15.7 to −4.8 for the most down regulated genes.
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