Sentence examples for most reduced expression from inspiring English sources

The gene in this interval with the most reduced expression in laz1-1 wasequenceded.

Major candidates were verified by quantitative RT-PCR, including the candidate with the most reduced expression, Kctd14, and two candidates that were dramatically up-regulated, Cap1 and Vav2.

In line with this, the genes that had the most reduced expression included those encoding key regulators of glycogenolysis (PYGM), fatty acid oxidation (CPT1B) and preservation of ATP formation (AMPD1).

The gene with the most reduced gene expression was sequenced.

Most important, reduced expression of the adherens junction glycoprotein E-cadherin has been linked to poor patient outcome in diverse carcinomas (Schipper et al, 1991; Umbas et al, 1994).

The genes most differentially expressed, with reduced expression in cartilage from older donors, included two involved in Wnt signalling: carboxypeptidase Z and chromosome 8 open reading frame 4. Furthermore, the abundance of three other genes involved in Wnt signalling (secreted frizzled-related protein 2, Wnt11 and Wnt inhibitory factor-1) were also reduced in old cartilage.

When we examined the Axin status of tumour cells that had invaded lymph vessels, their Axin expression was reduced or lost in most cases, suggesting that reduced expression of Axin initiates or promotes tumour progression.

Breast tumours with transcriptionally active NF-κB show reduced expression of most ER target genes, whereas ER+ breast tumours show reduced expression of most NF-κB target genes.

Including these genesets in our pathway analysis led to the identification of the cytotoxic cell subset as the most significant geneset with reduced expression in T2DM patients (Fig.  2 and Table  3).

Strikingly, ninety-six of the 100 most differentially expressed genes showed a reduced expression after fat loss.

Microarray analyses of fetal lungs performed in these studies show that expression of genes involved in the immune response and host defence are among the most highly differential, usually with reduced expression compared to wildtype.