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Table 2 shows a list of the 20 most recurrent genes obtained.
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Not surprisingly, TP53 and PIK3CA were among the three most recurrent mutated genes in this series of IMPCs.
Most recurrent fusion genes have been identified in leukemias, lymphomas, and soft tissue sarcomas where cytogenetic approaches to detect chromosomal aberrations using spectral karyotyping, fluorescent in situ hybridization, and flow cytometry have been developed [ 5].
The c.2991+1655A>G, c.4723A>T (p.Lys1575X) and c.3310-1_3310delinsAA mutations were the most recurrent, with gene-specific allele frequencies of 49%, 11 % and 6, respectively.
The p.Gln87Leu substitution had previously been reported as a rare somatic event in lung carcinoma, and mutations affecting Gln are among the most recurrent oncogenic lesions in RAS genes (COSMIC database, http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/).sanger.ac.uk/cancergenome/projects/cosmic/
MDM2 amplification is one of the most frequently observed recurrent gene amplifications in The Cancer Genome Atlas pan-cancer analyses of copy-number variations, and in particular sarcomas [ 33].
This frequency is significantly higher than most of the recurrent gene copy number variations reported in association with prostate cancer [ 11, 41- 44].
Of the 702 expressed genes of A. brasilense those related to bacterial adhesion, adaptation processes and nitrogen fixation were the most recurrent (Additional file 9: Table S7).
The most recurrent theme in McEwan's 10 novels is the sudden ambush of the safe and smug.
Operative urinary sites are the most recurrent infections.
Usually, most recurrent liver disease was detected by computed tomography.
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